Herpes Simplex Research

Cold Sores or Fever Blisters are caused by a virus, the Herpes Simplex Virus I (HSV I) and, less commonly, HSV II which normally affects the genital region. Client Reviews. Genital Herpes is normally caused by HSV II and less commonly by HSV I. HSV II is considered a Sexually Transmitted Disease (STD). This Virus hides or hibernates near your nervous system of the affected area indefinitely and thus a cure for Cold Sores or Genital Herpes has yet to be discovered. Effective treatment of the symptoms is the only relief and protection possible. During the replication phase of the hibernating virus, HSV moves out of the ganglia and sensitive blisters appear which can last up to 3 weeks. Oral prescription drugs are very effective in preventing the replication phase of the HSV II virus which consequently lulls the affected patient into thinking they have immunity in spreading the HSV II virus.

This is not true. HSV I and HSV II are highly contagious and can be spread during non outbreak situations.

This is further substantiated because the incidence of HSV II infection has not reduced despite 20 plus years of treatment with current oral prescriptions. Yet prescription oral antivirals continue to be one of the biggest cash cows for pharmaceuticals because this long term infection is embarrassing and private but mostly non-life-threatening. Imagine having a pill that stops the symptoms of a non-life-threatening, highly-contagious disease so you feel normal again yet does nothing to protect those intimate with you. Putting it in these terms, this prescription oral antiviral should sound like a scam to those affected and pharmaceuticals and public health officials alike are responsible.

The replication phase of herpes simplex virus is when our body reacts to the virus and antibodies are formed. Upon a reduction of the blisters, it is not uncommon to experience an explosion of additional blisters and this is called a super infection. At the genetic level, the UL52 gene product of Herpes Simplex Virus Type 1 (HSV-1) comprises of one subunit of a three protein helicase primase complex that is essential for replication of this double stranded DNA Virus. The functions of the individual subunits of the complex are not known with certainty, although it is clear that the UL8 subunit is not required for either helicase or primase activity. Understanding about other Herpes proteins such as Nectin-1 and UL29 provide advancements in Herpes Treatment and demonstrates pharmaceutical prowess regarding the microanalysis of already known herbal answers, 7-day pharmaceutical cream.

The likely inhibitory effects of Prunella is the function of the Herpes Simplex Virus Helicase Primase Complex which requires multiple gene inhibition and its expression also coincides with physical symptoms such as blister formation. These blisters typically recur at the same location of the lip, face or genital area. The fact that our antibodies that fight HSV cannot enter where the HSV hibernates prior to the replication phase or blister formation phase makes the irradication of HSV unlikely and the incidence of transmission has not reduced in the past 20 years. This is why treatment of Herpes centers around the cure of symptoms and hopefully transmission. Claims of a cure\ from the HSV Virus is a waste of your money although the 7 day cream is the first treatment capable of reducing transmission. One may infer that it has anti-viral activity different than acyclovir. On the other hand, pharmaceutical companies have identified sites on the above complex that inhibit its function and have made chemical structures that replicate this inhibition. Studies of herbal activities aid pharmaceutical research and their goal is to replicate this activity. Abreva and acyclovir are known pharmaceuticals that have partial topical viral inhibition with some resistence to HSV. Resistence makes the cream not effective after recurring use. The double stranded DNA Herpes Complex is more sophisticated and actually requires multiple genes to be inhibited to shut down the virus and stop symptoms and is similar to the treatment required for the more sophisticated expression of the reverse transcriptase virus or retrovirus, HIV. A Topical cream for the treatment of the Herpes Simplex Virus is important because it will likely reduce transmission or transfer of Herpes Simplex in the general population which oral preparations cannot offer but is not a substitute for protected sex due to other sexually transmitted diseases.

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